What is it about?
We characterized a putative RNA Binding Protein from Plasmodium vivax that is predicted to be targeted to the apicoplast (apiRBP). We used theoretical solvation analysis of a 3D model of the protein to design a soluble GFP-fused chimera and determined its ability to bind U-rich RNA stretches by calorimetry.
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Why is it important?
Altogether, apiRBP represents a very attractive tool for apicoplast transcriptional studies and anti-malarial drug design.
Perspectives
The future molecular characterizations of proteins with a crucial role in expression of plastid genes, such as apiRBP, are a promising target for RNA-based anti-malarial drugs.
Sofía Muñoz
University of Seville
Read the Original
This page is a summary of: A putative RNA binding protein from Plasmodium vivax
apicoplast, FEBS Open Bio, December 2017, Wiley,
DOI: 10.1002/2211-5463.12351.
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