What is it about?
The present study aimed to establish the diagnostic value of miR-101 in hepatocellular carcinoma (HCC). Then comprehensive bioinformatics methods were used to investigate the function and pathways of target genes of miR-101-3p and miR-101-5p associated with HCC, which we would like to investigate the prospective molecular mechanism of miR-101 in HCC preliminarily.
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Why is it important?
TCGA data mining revealed that miRNA-101 was under-expression in hepatocellular carcinoma (HCC). It is quite surprising that the comparison of miRNA-101 to the well-established HCC biomarker AFP revealed that the diagnostic value of miR-101-3p is higher than AFP. In addition, our results suggested that both miR-101-3p and miR-101-5p might pose as potential diagnostic markers in HCC, and exert their functions via targeting various prospective genes in the same pathways. This exploration will provide novel insights into HCC.
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This page is a summary of: Diagnostic value of strand-specific miRNA-101-3p and miRNA-101-5p for hepatocellular carcinoma and a bioinformatic analysis of their possible mechanism of action, FEBS Open Bio, December 2017, Wiley,
DOI: 10.1002/2211-5463.12349.
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