What is it about?
The present study aimed to establish the diagnostic value of miR-101 in hepatocellular carcinoma (HCC). Then comprehensive bioinformatics methods were used to investigate the function and pathways of target genes of miR-101-3p and miR-101-5p associated with HCC, which we would like to investigate the prospective molecular mechanism of miR-101 in HCC preliminarily.
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Why is it important?
TCGA data mining revealed that miRNA-101 was under-expression in hepatocellular carcinoma (HCC). It is quite surprising that the comparison of miRNA-101 to the well-established HCC biomarker AFP revealed that the diagnostic value of miR-101-3p is higher than AFP. In addition, our results suggested that both miR-101-3p and miR-101-5p might pose as potential diagnostic markers in HCC, and exert their functions via targeting various prospective genes in the same pathways. This exploration will provide novel insights into HCC.
Perspectives
The fact that miR-101-3p and miR-101-5p are involved in similar signaling pathways suggests that the expression of miR-101-3p and miR-101-5p is close in HCC tissues, and they may function cooperatively with each other in the differentiation, proliferation and development of HCC. Our results provide a deeper understanding of the role of miR-101 in HCC and facilitate the possible development of a miRNA-based targeted therapy of HCC.
Professor Gang Chen
First Affiliated Hospital of Guangxi Medical University
Read the Original
This page is a summary of: Diagnostic value of strand-specific miRNA-101-3p and miRNA-101-5p for hepatocellular carcinoma and a bioinformatic analysis of their possible mechanism of action, FEBS Open Bio, December 2017, Wiley,
DOI: 10.1002/2211-5463.12349.
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