What is it about?

There are some differences in cell morphology or protein expression between oogonia and spermatogonia in the African clawed frog Xenopus laevis.

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Why is it important?

Spermatogonia tend to retain PGC characteristics, compared to oogonia after metamorphosis in Xenopus laevis.

Perspectives

There might be stronger relationships between the DNA repair system and germ cell identity mediated through p53-cH2AX and Dmrt1 in males than in females in X. laevis. It is interesting to clarify how the relationships could protect germ cells from mutations or whether they are conserved in vertebrates

Dr Michihiko Ito
Kitasato University

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This page is a summary of: Sexually dimorphic expression of Dmrt1 and γH2 AX in germ stem cells during gonadal development in Xenopus laevis, FEBS Open Bio, February 2016, Wiley,
DOI: 10.1002/2211-5463.12035.
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