What is it about?
This study shows that for the first time GTEE promotes metabolic flexibility and plasticity, by displaying Uncoupling Protein 1 (UCP1)-positive browning features in the white adipocytes. The study highlights the physiological effects and the molecular events during the adipogenesis triggered by GTEE through a reported adaptive mechanism of intracellular mitochondria remodelling and chemical energy redox modifications.
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Why is it important?
It was an evidence for the hypothesis of GTEE will stimulate adipocyte browning and it reveals that the Ganoderma can act as an external stimulus to promote intracellular metabolism converting white adipocytes into brown-like adipocytes.
Perspectives
The result will shed new light on the strategy of preventing obesity in health care and medical use. It also provides additional scientific basis for the origins of "vital energy" regulated by Ganoderma and its association with metabolic and energy homeostasis
Professor Ming-Ching Kao
China Medical University
Read the Original
This page is a summary of: Proteomic profiling of Ganoderma tsugae
ethanol extract-induced adipogenesis displaying browning features, FEBS Letters, May 2018, Wiley,
DOI: 10.1002/1873-3468.13061.
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