What is it about?
The β-clamp is the processivity promoting factor for most of the enzymes in prokaryotic DNA replication; therefore it could be a crucial drug target in H. pylori.
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Why is it important?
We investigated the β-clamp from Helicobacter pylori, aiming to seek potential drug molecules against this gastric-cancer-causing bacterium. Successful identification of FDA-approved molecules against H. pylori may lead to better and faster drug development.
Perspectives
This work may advance the potential development of drugs targeting of β-clamp in H. pylori.
vijay verma
Central University of Rajasthan
Read the Original
This page is a summary of: Targeting the β-clamp in Helicobacter pylori
with FDA-approved drugs reveals micromolar inhibition by diflunisal, FEBS Letters, July 2017, Wiley,
DOI: 10.1002/1873-3468.12734.
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