What is it about?

Reported procedure is optimized for TBTA and can be applied to the synthesis of other triazolyl ligands (e.g., TTTA), which are commonly used to accelerate Cu-catalyzed azide alkyne cycloadditions and related reactions.

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Why is it important?

TBTA-copper complexes provide acceleration of CuAAC and should be used with challenging substrates (steric hindrance, presence of Cu-chelating groups, etc), which require accelerated temperature and prolonged reaction times.

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This page is a summary of: Cu-Catalyzed Azide-Alkyne Cycloaddition: Preparation of Tris((1-Benzyl-1H-1,2,3-Triazolyl)Methyl)Amine, November 2011, Wiley,
DOI: 10.1002/0471264229.os088.23.
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