What is it about?
This review demonstrates the role of magnetochemical and mechanochemical effects produced by magnetic nanoparticles alone and loaded with anticancer agents in response to constant magnetic and electromagnetic fields for modulation of tumor redox state.
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Why is it important?
By adjusting the parameters of constant magnetic and electromagnetic fields during treatment with magnetic nanoparticles, it is possible to modulate reactive oxygen species (ROS) production and switch redox signaling involved in ERK1/2 and NF-κB pathways from initiation of tumor growth to inhibition. Observations of tumor volume in different animal models and treatment combinations reported a 6-70% reduction as compared with conventional drugs.
Perspectives
Further multidisciplinary studies with more focus on the relationship between the electron transport processes in biomolecules and their effects on the tumor-host interaction should accelerate the clinical translation of magnetic nanotheranostics.
Valerii Orel
National Cancer Institute
Read the Original
This page is a summary of: Nanotherapy based on magneto‐mechanochemical modulation of tumor redox state, Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, October 2022, Wiley, DOI: 10.1002/wnan.1868.
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