What is it about?
A CYP2D6-based electrochemical biosensor was constructed by the covalent binding of the CYP2D6 enzyme to the carbon screen-printed electrode (C-SPE) surface. This biosensor preserved the enzymatic activity of CYP2D6 and catalyzed the electroreduction of MDMA and α-PVP by the DPV technique, showing low limits of detection and quantification.
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Why is it important?
The current dynamics of the illicit drug market demands new, simple and low-cost detection strategies. In this work we present, for the first time, the electrochemical detection of two NPS, amphetamine 3,4-methylenedioxymethamphetamine (MDMA) and the synthetic cathinone α-pyrrolidinopentiophenone (α-PVP), using an electrochemical biosensor based on cytochrome P450 2D6. (CYP2D6).
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This page is a summary of: Voltammetric Responses of a CYP2D6‐Based Biosensor to 3,4‐methylenedioxymethamphetamine (MDMA) and the Synthetic Cathinone α‐pyrrolidinopentiophenone (α‐PVP)., ChemistrySelect, November 2022, Wiley, DOI: 10.1002/slct.202202748.
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