What is it about?

A CYP2D6-based electrochemical biosensor was constructed by the covalent binding of the CYP2D6 enzyme to the carbon screen-printed electrode (C-SPE) surface. This biosensor preserved the enzymatic activity of CYP2D6 and catalyzed the electroreduction of MDMA and α-PVP by the DPV technique, showing low limits of detection and quantification.

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Why is it important?

The current dynamics of the illicit drug market demands new, simple and low-cost detection strategies. In this work we present, for the first time, the electrochemical detection of two NPS, amphetamine 3,4-methylenedioxymethamphetamine (MDMA) and the synthetic cathinone α-pyrrolidinopentiophenone (α-PVP), using an electrochemical biosensor based on cytochrome P450 2D6. (CYP2D6).


Electrochemical biosensors represent great opportunities to solve future analytical challenges, and the detection of drugs of abuse is no exception. Our work is an important contribution to a currently trending approach: New Psychoactive Substances (NPS).

Andres Felipe Lugo Vargas
Universidad Nacional de Colombia

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This page is a summary of: Voltammetric Responses of a CYP2D6‐Based Biosensor to 3,4‐methylenedioxymethamphetamine (MDMA) and the Synthetic Cathinone α‐pyrrolidinopentiophenone (α‐PVP)., ChemistrySelect, November 2022, Wiley,
DOI: 10.1002/slct.202202748.
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