What is it about?

2-thiazolines are very important structural motifs in pharmaceuticals, agrochemicals and in chemistry. In this mini review, I tried to highlight the metal mediated synthetic strategies and challenges of 2-thiazolines based on the literature up to 2020. It was found that most of these protocols involved the formation of both C-N and C-S bonds and the major challenges were the stereochemistry at C-4 position and C(2)-exomethine position. Moreover, the development of asymmetric processes was completely overlooked and hence the question arises -how could the site of selectivity be improved to get access to the desired structural units?

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Why is it important?

Various research groups have paid attention in last few decades to get access of stereochemically vibrant structures of 2-thiazolines due to their extensive applications in pharmaceuticals, agrochemicals and in chemistry. Metal-catalyzed reactions are often considered to achieve high molecular complexity and greater functional group compatibilities from easily accessible starting materials under milder reaction conditions and atom economical fashions. It is conceivable that a semi-quantitative and qualitative overview of the ongoing works is necessary to help guide the future work in this area. Hence, we were most interested to learn the existing challenges, targets that driven the development of metal catalysts and the areas that were improved by those strategies.


Here, the reaction scopes, limitations and the idea of mechanisms are discussed to understand the structure-based analysis. In addition, some plausible routes to get access to similar types of N,S-heterocycles are also suggested. I believe, this mini review might be a good addition to follow the chemistry in these areas of research.

Dilruba A. Popy
Bangabandhu Sheikh Mujibur Rahman Science and Technology University

Read the Original

This page is a summary of: Metal Mediated Synthesis of 2‐thiazolines: Access to Regio‐ and Stereoselective N , S ‐heterocycles, ChemistrySelect, April 2021, Wiley, DOI: 10.1002/slct.202100263.
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