What is it about?
Rifampicin can cause P-gp induction- and inhibition-mediated DDIs with P-gp substrates in clinical. Our established PBPK model successfully predicted the P-gp-mediated DDIs and offered insights into P-gp induction levels in the intestine, liver, and kidney.
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Why is it important?
Although the contribution of P-gp-mediated DDIs in the intestine, liver, and kidney was not clarified, our simulations have made it clear that the intestinal P-gp was impacted by rifampicin-mediated DDIs much more than hepatic or renal P-gp.
Perspectives
Our rifampicin PBPK model may enable net quantitative DDI predictions with various P-gp substrates that are in clinical use or under development.
Ryuta Asaumi
Astellas pharma Inc.
Read the Original
This page is a summary of: Robust
PBPK
Model of Rifampicin for Predicting
Drug‐Drug
Interactions via P‐gp Induction and Inhibition in Intestine, Liver, and Kidney, CPT Pharmacometrics & Systems Pharmacology, May 2022, Wiley,
DOI: 10.1002/psp4.12807.
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