What is it about?
CASP is an international bianual protein structure prediction competition. This article reports the accuracy of protein assembly predictions compared to the experimentally determined structures and ranks predictor groups based on their performance in the 12th edition of CASP in 2016.
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Why is it important?
Proteins carry out their functions in the cell as folded three-dimensional structures, which further assemble into higher order macromolecular complexes. Although it can be experimentally shown that protein folding and association is solely determined by the sequence of amino acids, prediction of protein structures and complexes is still an open challenge of vital importance for biotechnology and biomedicine. The CASP experiment serves the protein structure prediction community as a critical and independent assessment of the state-of-the-art of prediction methods.
Perspectives
This article reports the first official attempt to critically assess protein assembly predictions in CASP. Although the participation was low, there was a large diversity of prediction methods and some of the predicted assemblies were very close to the experimental structures. The results also show that methods that predict protein assembly are technically behind tertiary structure prediction methods, and they have room for improvement specially for protein assemblies without known templates.
Mr Aleix Lafita
European Molecular Biology Laboratory
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This page is a summary of: Assessment of protein assembly prediction in CASP12, Proteins Structure Function and Bioinformatics, November 2017, Wiley,
DOI: 10.1002/prot.25408.
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