What is it about?
We conducted an observational study to find out if the removal of more pelvic lymph nodes during prostate cancer surgery offers a therapeutic benefit ( removal of occult micrometastases) in addition to a staging benefit (more accurate staging and better patient selection for subsequent treatment).
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Why is it important?
Our findings not only suggest that the removal of more pelvic lymph nodes during prostate cancer surgery is beneficial but also that this benefit is not restricted to a staging benefit and probably involves a therapeutic benefit by the removal of occult micrometastases.
Perspectives
In this study we used for the first time a causal mediation framework to disentangle two causal pathways. Although methodologically challenging, such an approach is very enriching as it finally helps to correctly define confounding and mediating variables.
Dr. Marian Severin Wettstein
Universitat Zurich
Read the Original
This page is a summary of: Benefit of a more extended pelvic lymph node dissection among patients undergoing radical prostatectomy for localized prostate cancer: A causal mediation analysis, The Prostate, February 2021, Wiley,
DOI: 10.1002/pros.24105.
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