What is it about?

The 4-aryl 1,4-Dihydropyridines, also known as Hantzsch esters, are important structural units in Medicinal Chemistry, whose most important application is perhaps their use as modulators of calcium channels in blood pressure control, such as Nifedipine.

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Why is it important?

Fluorescent molecules can act as Molecular Probes that can be visualized "in vitro" or "in vivo" by fluorescence microscopy, allowing their localization inside cell tissue.


A associação de propriedades fluorescentes à moléculas biologicamente ativas pode permitir a melhor compreensão do mecanismos pelos quais estas moléculas atuam como drogas.

Prof. Dennis Russowsky
Universidade Federal do Rio Grande do Sul

Read the Original

This page is a summary of: Photophysical properties of a series of 4‐aryl substituted 1,4‐dihydropyridines, Journal of Physical Organic Chemistry, January 2012, Wiley, DOI: 10.1002/poc.2916.
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