What is it about?
We explain the mortality and morbidity of gestational malnutrition resulting from severe hyperemesis gravidarum both as it affects both mother and fetus. We also review the metabolism of the vitamin thiamin (or B1) in the treatment of Wernicke's and potentially why in some cases it is ineffective.
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Why is it important?
Only 20% of cases of Wernicke's encephalopathy are discovered in living patients; the majority of cases are found at autosphy. Wernicke's encephalopathy is a specific form of malnutrition of the brain and nervous system and has an extremely high fatality rate. Wernicke's can happen to many types of patients--including women with hyperemesis gravidarum, eating disorders, homeless persons, refugees, prisoners on hunger strikes as well as those persons abusing alcohol..
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This page is a summary of: Gestational malnutrition, hyperemesis gravidarum, and Wernicke's encephalopathy: What is missing?, Nutrition in Clinical Practice, October 2022, Wiley, DOI: 10.1002/ncp.10913.
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