What is it about?
Recurrent implantation failure is the most difficult challenge in human IVF cycles. There is a growing demand for medicines that enhance implantation rate and probability of successful implantation. Recently, intrauterine infusion of autologous platelet-rich plasma (PRP) has been suggested to enhance the endometrial receptivity in RIF patients. PRP is rich in both growth factors and microRNAs (miRNA) ⁴.For the first time we showed that mir-21-3p can be a valuable biomarker for the prediction of pregnancy chance in infertile patients (RIF) treated with PRP.
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Why is it important?
Intrauterine injection of platelet-rich plasma (PRP) has been suggested as a medical cure for infertile patients. In the other hand PRP is rich in both microRNAs (like mir-21-3p) and growth factors which can enhance the proliferation of uterus cells. It has also been analyzed that follicular fluid IGF-I is in association with embryo quality and affects pregnancy rate in IVF cycles.
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This page is a summary of: The expression level of mir‐21‐3p in platelet‐rich plasma: A potential effective factor and predictive biomarker in recurrent implantation failure, Molecular Reproduction and Development, July 2022, Wiley, DOI: 10.1002/mrd.23636.
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