What is it about?

Spinal cord injury (SCI), a severe neurological disorder, is reported to be a major cause of paralysis and its morbidity reaches up to 1.4 million in America. MicroRNAs (miRNAs) exert functions in spinal cord injury (SCI). MiR-33-5p level is downregulated in the rats with SCI. We herein investigate the biological functions and underlying mechanisms of miR-33-5p.

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Why is it important?

MiR-33-5p level was downregulated in SCI rats. MiR-33-5p upregulation alleviated the leakage of BSCB induced by SCI and improved neurological functions of SCI rats. MiR-33-5p bound to Rps6kb1 3’UTR. Rps6kb1 expression was upregulated after SCI. MiR-33-5p alleviates the LPS-induced cell apoptosis by targeting Rps6kb1


MiR-33-5p ameliorates SCI in rats and inhibits the LPS-induced apoptosis of PC12 cells.

yuanshi zhang
China Medical University

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This page is a summary of: MiR ‐33‐5p alleviates spinal cord injury in rats and protects PC12 cells from lipopolysaccharide‐induced apoptosis, The Kaohsiung Journal of Medical Sciences, November 2022, Wiley, DOI: 10.1002/kjm2.12610.
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