What is it about?

Newborn rabbits after being subjected to hypoxia (cerebral palsy model) were tested for nociception behavior and had their spinal cord analyzed. They showed to have enhanced nociception behavior and expansion of associated primary afferents verified in slices of their spinal cords, as compared to control animals (not subjected to hypoxia).

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Why is it important?

This was the first time that an enhanced sensitivity/pain was shown in an animal model of cerebral palsy.

Perspectives

This may be important as a tool to develop therapies for humans addressing this dysfunctional issue.

Clarissa Fantin Cavarsan Muller
University of Rhode Island

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This page is a summary of: Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy, Journal of Neuroscience Research, July 2022, Wiley, DOI: 10.1002/jnr.25108.
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