Neuroactive molecules and growth factors modulate cytoskeletal protein expression during astroglial cell proliferation and differentiation in culture

  • Effect of Steroid Hormones and GFs in Astrocyte Cultures
  • Vincenzo Bramanti, Sonia Grasso, Daniele Tibullo, Cesarina Giallongo, Rita Pappa, Maria Violetta Brundo, Daniele Tomassoni, Maria Viola, Francesco Amenta, Roberto Avola
  • Journal of Neuroscience Research, October 2015, Wiley
  • DOI: 10.1002/jnr.23678

Effect of Steroid Hormones and Growth Factors in primary Astrocyte Cultures


Dr Vincenzo Bramanti
University of Catania

This study provides evidence of the intertwined dialogue between neuroactive molecules such as dexamethasone and both “competence” and “progression” growth factors (GFs) in regulating astrocyte cytoskeletal proteins and extracellular signal-regulated kinase 2 expression during astroglial cell proliferation and differentiation processes. Because increasing evidence suggests that these well-known neuroactive molecules exert significant neuroprotective effects against a variety of neurodegenerative pathologies, these findings underscore an interesting neurosteroid–GF cross-talk that might have significant implications for future therapeutic approachs to neurologic disorders associated with astrogliosis.

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