What is it about?

To date, there are still no licensed antiviral agents available to treat EV-A71 infection,one of the major causative agents of hand-foot-and-mouth disease. In this study, we investigated the roles played by host kinases in EV-A71 replication and identified Rock inhibitors (host kinases) as a potential antiviral agent against EV-A71 replication. More importantly, we showed that siRNA depletion of Rock1 can dramatically suppress the EV-A71 replication and concluded that Rock1 is a novel host factor of EV-A71, which can be further explored as a drug target against EV-A71 infection.

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Why is it important?

The knowledge obtained from this study will provide a scientific basis for identification of host factor-based targets for development of prophylactics and therapeutics against enterovirus infection.

Perspectives

We hope that it can be developed as a drug target to treat EV-A71, bringing good news to patients with hand, foot and mouth disease.

Xiaoyu ZHAO
Fudan University

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This page is a summary of: Rock1 is a novel host dependency factor of human enterovirus A71: Implication as a drug target, Journal of Medical Virology, July 2022, Wiley, DOI: 10.1002/jmv.27975.
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