What is it about?

The primary (amino acid sequence and composition) and higher order structures of peptides determines the architecture of the molecule as a whole, including its conformational specificities and in the long run its biological properties. Therefore, determination of the primary and higher order structures are the basic requisites for further progress in physicochemical and biological investigation of peptides.

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Why is it important?

The sequence of the amino acids in a peptide determines the properties of the molecule. The slightest change in the primary or higher order structures of therapeutic peptides and/or peptide related impurities can significantly impact its safety, efficacy and immunogenicity. Peptide structures and activities are inherently sensitive to temperature. The recommended storage temperature of Orgalutran® is 15°C- 30°C. During shipping, there is a chance of extreme temperature changes. The aim of the present work is to evaluate the temperature effect on the purity, primary and higher order structures of Ganirelix in the injectable formulation.

Perspectives

It was a great pleasure to write this article on peptide molecule which has been extensively used for the fertility treatment to control ovulation in women during In Vitro Fertilization (IVF) Process. This article leads to a greater involvement in Women's health research.

Mr. Kumarswamy Ummiti
Koneru Lakshmaiah Education Foundation

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This page is a summary of: Evaluation of temperature, excipients impact on the primary structure of Ganirelix in an injectable formulation, and comparison with Orgalutran® using MALDI-TOF/TOF-MS, Journal of Mass Spectrometry, August 2020, Wiley, DOI: 10.1002/jms.4610.
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