What is it about?

We have shown that pure antibodies isolated from the serum of patients with schizophrenia can not only bind the myelin basic protein, but also destroy this antigen.

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Why is it important?

Anomalies of myelination and hypomyelination can be observed in schizophrenia, which leads to a violation of the nerve impulse. Discovered antibodies with proteolytic activity can play an important role in this process. These data indicate a new pathological mechanism in schizophrenia. We suggest that anti-inflammatory therapy for schizophrenia may have a beneficial effect.

Perspectives

Further studies are needed to elucidate the effects of antibodies with proteolytic activity, as well as the effect of anti-inflammatory therapy in schizophrenia.

Evgeny Ermakov
Institute of Chemical Biology and Fundamental Medicine

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This page is a summary of: Autoimmunity and immune system dysregulation in schizophrenia: IgGs from sera of patients hydrolyze myelin basic protein, Journal of Molecular Recognition, August 2018, Wiley, DOI: 10.1002/jmr.2759.
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