What is it about?
2,3-Diaryloxirane-2,3-dicarbonitriles have employed in heterocyclic synthesis in many organic reactions. Authors highlight its use as intermediate in the synthesis of various organic compounds through the reaction with different nitrogen nucleophiles as methyl hydrazine, thiourea, thiosemicarbazide, methylglycinate, and others to furnish new heterocyclic derivatives.
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Why is it important?
They are also used as key starting materials to construct some important heterocycles. Structures of all newly synthesized products are substantiated by studying their micro analytical and spectral data. Some of newly synthesized compounds were evaluated for their in vitro cytotoxic effects against a panel of three human tumor cell lines, namely, Hep-G2, Hela, and MCF-7.
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This page is a summary of: Synthesis and QSAR Study of Some Novel Heterocyclic Derivatives as In Vitro
Cytotoxic Agents, Journal of Heterocyclic Chemistry, November 2018, Wiley, DOI: 10.1002/jhet.3417.
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