What is it about?
Epithelial-derived extracellular vesicles (EVs) carry iron-loaded ferritin. These EVs are recognized by macrophage membrane protein MSR1 (macrophage scavenger receptor 1) and internalized by macrophages. The internalization and its subsequent effects contribute to IBD.
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Why is it important?
Blockage of the internalization mentioned above ameliates the inflammatory symptoms and likely benefits patients.
Perspectives
Fucoidan, a MSR1 inhibitor, can be combined with conventional therapy in clinical trials. It is also considered to have other immune benefits, making it worthy of a try.
Kuanyu Li
Nanjing University
Read the Original
This page is a summary of: Macrophages Internalize Epithelial‐Derived Extracellular Vesicles That Contain Ferritin via the Macrophage Scavenger Receptor 1 to Promote Inflammatory Bowel Disease, Journal of Extracellular Vesicles, June 2025, Wiley,
DOI: 10.1002/jev2.70105.
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