What is it about?
This paper describes genetic screens in the worm C. elegans that attempt to identify what phosphatases regulate muscle.
Why is it important?
Muscle loss is an important problem in the clinic both for people as they naturally age (a growing problem) and in a diverse set of clinical diagnoses. Unfortunately, we do not have good pharmacologic interventions to prevent muscle loss. This gap in knowledge is largely down to lack of molecular understanding, and therefore ability to target, mechanisms of loss of muscle mass.
Read the Original
This page is a summary of: Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans
muscle, Journal of Cachexia Sarcopenia and Muscle, May 2017, Wiley, DOI: 10.1002/jcsm.12196.
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