What is it about?
Epigenetic factors and TFs regulate the activation or repression of HSCs genes, playing a central role in normal hematopoiesis. Herewith, we summarize how dysregulations in the expression of genes related to self‐renewal, proliferation, and differentiation of HSCs caused by changes in epigenetic modifications and transcriptional networks lead to clonal expansion and leukemic transformation.
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Why is it important?
It appears that epigenetic regulators and TFs have important roles in protecting self‐renewal of both HSCs and leukemic stem cells (LSCs). Therefore, the evaluation of changes in TFs and epigenetic regulators as well as their functional pathways in genomic instability of HSCs could yield high‐value targets for leukemia therapy.
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This page is a summary of: Altering chromatin methylation patterns and the transcriptional network involved in regulation of hematopoietic stem cell fate, Journal of Cellular Physiology, February 2020, Wiley, DOI: 10.1002/jcp.29642.
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