What is it about?
Epigenetic factors and TFs regulate the activation or repression of HSCs genes, playing a central role in normal hematopoiesis. Herewith, we summarize how dysregulations in the expression of genes related to self‐renewal, proliferation, and differentiation of HSCs caused by changes in epigenetic modifications and transcriptional networks lead to clonal expansion and leukemic transformation.
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Photo by National Cancer Institute on Unsplash
Why is it important?
It appears that epigenetic regulators and TFs have important roles in protecting self‐renewal of both HSCs and leukemic stem cells (LSCs). Therefore, the evaluation of changes in TFs and epigenetic regulators as well as their functional pathways in genomic instability of HSCs could yield high‐value targets for leukemia therapy.
Perspectives
Writing this article was a great pleasure as it paved the way for my future research area which is going to be exploring the role of transcriptional factors in embryonic stem cells' (ESCs) fate decision. I hope this article provide helpful information for scientists. More than anything else, and if nothing else, I hope you find this article thought-provoking.
Mohammad Shokouhian
Iran University of Medical Sciences
Read the Original
This page is a summary of: Altering chromatin methylation patterns and the transcriptional network involved in regulation of hematopoietic stem cell fate, Journal of Cellular Physiology, February 2020, Wiley,
DOI: 10.1002/jcp.29642.
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