Cover Image, Volume 232, Number 4, April 2017

Federico Castro-Muñozledo, Diana G. Meza-Aguilar, Rocío Domínguez-Castillo, Veremundo Hernández-Zequinely, Erika Sánchez-Guzmán
  • Journal of Cellular Physiology, December 2016, Wiley
  • DOI: 10.1002/jcp.25741

Vimentin is a possible marker of corneal epithelial stem/progenitor cells

What is it about?

This micrograph corresponds to the paper that describes a possible interaction between keratin and vimentin cytoskeletal networks together with hemidesmosomal components such as alpha 6 beta 4 integrin, in order to enhance cell motility during wound healing and cell migratory movements linked to embryo development. The micrograph appears in Figure 1 in J Cell Physiol. 2017 Apr;232(4):818-830. doi: 10.1002/jcp.25487.

Why is it important?

We consider that this work is important due to the possible association between the vimentin/keratin networks in early differentiating epithelial cells and epithelial progenitors, which may be actively involved in migratory movements during wound healing and development.

Perspectives

Dr Federico Castro-Munozledo (Author)
Centro de Investigación y de Estudios Avanzados del IPN

I believe that our results open new insights on epithelial cell motility. One of the major questions that should be approached is related with the differences among transformed cell populations in which vimentin cytoskeleton plays a major role in cell motility, and progenitor cell populations or early differentiating cells that co-express and co-polymerize vimentin and keratin filaments to express a high motile phenotype. Are they similar?. On the other hand is will be interesting to analyze the role of alpha 6 integrin isoforms in cell migration.

The following have contributed to this page: Dr Federico Castro-Munozledo