Vimentin and epithelial cell motility
What is it about?
Together with two previous publications, this paper proposes a possible interaction between keratin and vimentin cytoskeletal networks together with hemidesmosomal components such as alpha 6 beta 4 integrin, in order to enhance cell motility during wound healing and cell migratory movements linked to embryo development. Such interaction may change cytoplasm fluidity and support organelle translocation during cell movement. The proposed interaction involves the copolymerization of Vimentin and Keratin filaments at the migratory edges of cells, and their interaction with Extracellular Matrix, a task achieved by relocation of alpha 6 beta 4 integrin into focal adhesion plaques, and its association with plectin as an integrator molecule mediating such interaction.
Why is it important?
We consider that this work is important due to the possible association between the vimentin/keratin networks in early differentiating epithelial cells and epithelial progenitors, which may be actively involved in migratory movements during wound healing and development.
The following have contributed to this page: Dr Federico Castro-Munozledo
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