What is it about?
Post-translational modifications like S-nitrosylation via nitric oxide changes cofilin-1 activity to regulate actin cytoskeleton reorganization and thus increasing cell motility and migration in response to VEGF in endothelial cells.
Why is it important?
NO is an important gaseous signaling molecule that regulates Cell migration via modification of protein functions on reactive cysteines. Cell migration is fundamental to many physiological and pathophysiological processes.
The following have contributed to this page: Dongbao Chen