S-nitrosylation of Cofilin-1 Serves as a Novel Pathway for VEGF-Stimulated Endothelial Cell Migration

  • COFILIN-1S-NITROSYLATION AND CELL MIGRATION
  • Hong-hai Zhang, Wen Wang, Lin Feng, Yingying Yang, Jing Zheng, Lan Huang, Dong-bao Chen
  • Journal of Cellular Physiology, October 2014, Wiley
  • DOI: 10.1002/jcp.24724

What is it about?

Post-translational modifications like S-nitrosylation via nitric oxide changes cofilin-1 activity to regulate actin cytoskeleton reorganization and thus increasing cell motility and migration in response to VEGF in endothelial cells.

Why is it important?

NO is an important gaseous signaling molecule that regulates Cell migration via modification of protein functions on reactive cysteines. Cell migration is fundamental to many physiological and pathophysiological processes.

Perspectives

Dongbao Chen

S-nitrosylation of cofilin-1 offers a pathway for mediating enhanced cell migration in angiogenesis in physiological processes and pathological processes in association with increased VEGF production.

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http://dx.doi.org/10.1002/jcp.24724

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