Protein Kinase CK2 Inhibition Induces Cell Death via Early Impact on Mitochondrial FunctionFatima Qaiser, Janeen H. Trembley, Betsy T. Kren, Jing-Jiang Wu, A. Khaliq Naveed, Khalil Ahmed
- Journal of Cellular Biochemistry, October 2014, Wiley
- DOI: 10.1002/jcb.24887
Protein Kinase CK2 and Cell Death Regulation
What is it about?
Protein kinase CK2 is a potent suppressor of apoptosis (cell death). Elevation of CK2 suppresses cell death and inhibition of CK2 induces cell death. This work identifies early rapid action on mitochondria affecting mitochondrial membrane potential and associated calcium flux changes as a mechanism by which CK2 downregulation leads to cell death.
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