What is it about?
Silver nanoparticle (AgNP) is an important ingredient in more than 24% nanotechnology based consumer products. We show here for the first time that entrapping AgNP in liposomes allow for easy entry into the cells to deliver more AgNP into the cell than the unmodified type.
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Why is it important?
AgNP is often present in this products in high concentration which increases risk of adverse effects based on human exposure. As such, modifying AgNP to enhance its toxic on effect on bacterial and cancer cells for instance, will help reduce the concentration that is applied in these products. Our findings showed that entrapping AgNP in the liposome did improve the toxic effect on a blood cancer cell type (THP1) without causing production of oxygen radicals which are common to AgNP. This finding will allow reduction of the amount of AgNP that is undelivered into the cell which eventually enters the ecosystem, reducing human exposure.
Perspectives
Writing this article means a lot to me as it was my first published paper. I really do hope that scientist take on board the proof of concept in entrapping nanoparticles in liposomes to improve their effectiveness, reduce applicatio concentration and subsequently the amount nanoparticles leaching into our ecosystem.
Azeez Yusuf
Dublin Institute of Technology
Read the Original
This page is a summary of: Liposomal encapsulation of silver nanoparticles enhances cytotoxicity and causes induction of reactive oxygen species-independent apoptosis, Journal of Applied Toxicology, November 2017, Wiley,
DOI: 10.1002/jat.3566.
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