Omental adipocyte-derived fibroblast: a novel minions of ovarian cancer deriving from fat cell.

What is it about?

• Ovarian cancer cells show selectivity to the adipocyte-rich tissues such as omentum upon dissemination, and proliferates there at a rate higher than that of the primary lesion, however, there are still a lot of unclear points about the detailed mechanism. • Ovarian cancer cells promote the dedifferentiation process of omental adipocytes through Wnt signaling and induce omental adipocyte-derived fibroblasts (O-ADF). • O-ADFs thus generated promote the growth and migration of ovarian cancer cells and contributes to tumor progression at peritoneal dissemination site.

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Photo by Fuu J on Unsplash

Photo by Fuu J on Unsplash