Hyperoxia promotes polarization of the immune response in ovalbumin‐induced airway inflammation, leading to a TH 17 cell phenotype

  • Akinori C. Nagato, Frank S. Bezerra, André Talvani, Beatriz J. Aarestrup, Fernando M. Aarestrup
  • Immunity Inflammation and Disease, June 2015, Wiley
  • DOI: 10.1002/iid3.71

Medical oxygen modifies the cellular immune response in experimental model of asthma.

What is it about?

The oxygen-induced oxidative stress is able to modify the cellular profile during inflammation in experimental model of asthma.

Why is it important?

We have shown for the first time that medical oxygen intensifies the Th17 cell-mediated immune response during experimental model of asthma.


Akinori Cardozo Nagato
Federal University of Juiz de Fora

Our expectation is to understand the relationship between oxygen-induced oxidative stress and the Th17 cell-mediated immune response in the pathophysiology of experimental asthma. We hope in the future that this knowledge will contribute with other researchers who aim to control the asthma inflammatory response in humans.

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The following have contributed to this page: Akinori Cardozo Nagato