What is it about?
Mice deficient of TGR5 was used to study bile acid signaling in extended fasting. Results showed growth hormone signaling may be involved in regulation of a male-dominant enzyme CYP7B1 in the alternative bile acid synthesis pathway and lipid metabolism.
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Why is it important?
This study discovered a role of TGR5 in bile acid metabolism in fasting and TGR5 may mediate the brain to liver axis to control lipid and bile acid metabolism.
Perspectives
TGR5 is widely distributed in most tissue except liver. The role TGR5 in metabolism is not clear and require further study. Targeting to TGR5 may have potential for developing therapeutic drugs for treating metabolic disorders.
Professor john Chiang
Read the Original
This page is a summary of: G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice, Hepatology, July 2016, Wiley,
DOI: 10.1002/hep.28707.
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