Predictive markers for delayed lymph node metastases and survival in early-stage oral squamous cell carcinoma

  • Predictive markers for delayed lymph node metastases and survival in early-stage oral cancer
  • Ivica Luksic, Petar Suton
  • Head & Neck, December 2016, Wiley
  • DOI: 10.1002/hed.24667

Predictive markers in early-stage oral cancer

What is it about?

Lymph node metastases are most important prognostic factor in oral cancer. We have shown for the first time that molecules of the tumor stroma (laminin and fibronectin) contribute to the tumor progression in terms of lymph node metastases occurence.

Why is it important?

In this article we identified three crucial prognosticators (poorly differentiated tumors, low laminin and high fibronectin expression) of lymph node metastases in clinically node-negative settings. Two significant finding are that: a) tumor stroma facilitate progression of the oral cancer and b) combination of these factors can help guide more precisely surgical treatment and indication for elective neck dissection in oral cancer patients.

Perspectives

M.D., Ph.D. Petar Suton
University Hospital for Tumors, University Hospital Centre Sisters of Mercy

Writing this article was a great pleasure as it has co-author with whom I have had long standing friendship and collaboration.

Read Publication

http://dx.doi.org/10.1002/hed.24667

The following have contributed to this page: M.D., Ph.D. Petar Suton