What is it about?

A new high‐quality standardized T1‐weighted template of the older adult brain as part of an ongoing project to develop a comprehensive older adult brain atlas named Multichannel Illinois Institute of Technology & Rush university Aging (MIITRA) atlas, and systematically compare the new template and several other standardized and study specific templates in terms of image quality, performance in spatial normalization of older adult data and detection of small inter‐group morphometric differences, and representativeness of the older adult brain.

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Why is it important?

The new MIITRA T1‐weighted template combines a number of desirable properties for use in studies on older adults over other available standardized and SS templates: (a) it is characterized by high image quality, (b) provides consistently high inter‐subject spatial normalization accuracy for older adult data, (c) allows detection of small inter‐group morphometric differences, (d) is representative of the older adult brain, (e) allows integration of results across studies, and because it is standardized, (f) eliminates time‐consuming and potentially sub‐optimal SS template construction.


This paper describes systematically the construction and evaluation of a high-performing T1-weighted structural template designed specifically for use in older-adults as a part of an ongoing development of a comprehensive older adult MIITRA atlas.

Illinois Institute of Technology

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This page is a summary of: Development and evaluation of a high performance T1 ‐weighted brain template for use in studies on older adults, Human Brain Mapping, January 2021, Wiley, DOI: 10.1002/hbm.25327.
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