What is it about?
Microglia constitutes the immuno-competent cells of the brain and, thus, are usually studied in the context of disease. Nonetheless, microglia has a pivotal role in the normal development of neural circuits. In this paper, we explore the consequences of the interruption of a communication pathway between neurons and microglia from the early changes in population activity in the neonate to its ultimate consequences in the adult organism.
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Why is it important?
Our findings add new insights into the role of neuron-microglia communication and interaction in the development and maintenance of neural circuits and how this affects behavior and cognitive functions. This also sheds some light on its potential involvement in the etiology of neuropsychiatric disorders such as anxiety, autism, and schizophrenia.
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This page is a summary of: Abnormal innate and learned behavior induced by neuron–microglia miscommunication is related to CA3 reconfiguration, Glia, May 2022, Wiley, DOI: 10.1002/glia.24185.
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