What is it about?

Nicotine is the major addictive component of tobacco and electronic vaping system. In this research article, the researchers show that nicotine causes alteration of morphology and function of astrocytes in the brain.

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Why is it important?

Nicotinic receptors are targeted for therapeutic delivery in substance abuse as well as in other neurological disorder. In this work, the researchers showed that nicotine directly affects astrocyte activity through nicotinic receptors. These findings can provide insights on alternative targets for therapeutic applications of drugs in the brain.


It was a great pleasure to work on this project. I got to collaborate with many other researchers and they were very helpful. We believe this publication helped to establish the important role of astrocytes in substance use disorder.

Surya P Aryal
University of Kentucky

Read the Original

This page is a summary of: Nicotine induces morphological and functional changes in astrocytes via nicotinic receptor activity, Glia, April 2021, Wiley,
DOI: 10.1002/glia.24011.
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