Acid-Free Synthesis of Carbazoles and Carbazolequinones by Intramolecular Pd-Catalyzed, Microwave-Assisted Oxidative Biaryl Coupling Reactions - Efficient Syntheses of Murrayafoline A, 2-Methoxy-3-methylcarbazole, and Glycozolidine

  • Vellaisamy Sridharan, M. Antonia Martín, J. Carlos Menéndez
  • European Journal of Organic Chemistry, September 2009, Wiley
  • DOI: 10.1002/ejoc.200900537

What is it about?

A mild and efficient methodology for the synthesis of oxy- genated carbazoles from diarylamines under non-acidic con- ditions was developed, based on a palladium-catalyzed, mi- crowave-assisted double C–H bond activation process. This new protocol was successfully applied to the synthesis of three naturally occurring carbazoles, namely murrayafoline A, 2-methoxy-3-methylcarbazole, and glycozolidine.

Why is it important?

The scope of the reaction was also expanded to include the syn- thesis of benzo fused carbazolequinones.

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The following have contributed to this page: M. Antonia Martín