What is it about?
During Trypanosoma cruzi infection anti-parasite response is delayed in time. After skin-infection, there is a failure in leukocyte mobilization into the parasite´s site of entry, followed by the recruitment of monocytes to secondary lymphoid organs. We have shown that monocyte-derived cells result critical in the control of the parasite spreading but also in sustaining its persistence into the host.
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Why is it important?
Our findings demonstrate the complexity of the myeloid compartment during this protozoan infection. This open new perspectives in order to design strategies for immunotherapy.
Perspectives
Given monocytes-derived cells heterogeneity, further advances in the field will enable a better classification of these cells and their use as targets for therapy.
Dr Carolina V Poncini
IMPaM, University of Buenos Aires-CONICET
Read the Original
This page is a summary of: Dual role of monocyte-derived dendritic cells in Trypanosoma cruzi
infection, European Journal of Immunology, August 2017, Wiley,
DOI: 10.1002/eji.201646830.
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