What is it about?
The methodology involved in developing a GC method for the quantitation of theophylline in serum. A non-specific UV-spectrophotometric method was currently in use at the time. Xanthines that were ingested such as caffiene and present in the body such as uric acids could interfere and exaggerate the concentrations of theophylline in the blood.
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Why is it important?
It provided a first alternative method to the UV-method
Perspectives
HPLC methods replaced the GC method over time.
Dr. Frank A Chrzanowski
ExpertPharma, LLC
Read the Original
This page is a summary of: Kinetics of intravenous theophylline, Clinical Pharmacology & Therapeutics, August 1977, Wiley,
DOI: 10.1002/cpt1977222188.
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