What is it about?

Cardiovascular diseases are the leading cause of disability and premature death worldwide. This real-world evidence (RWE) study showed a high risk of cardiovascular events or death, especially six months after the first event. In the five years following the first cardiovascular event, 41.5 percent of patients died or survived the second event. However, death was the most common event following the first cardiovascular event. In addition, the number of deaths and recurrences was particularly high in the six months following the first event.

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Why is it important?

Large numbers of patients live with cardiovascular diseases and thus are at risk of having a cardiovascular event: myocardial infarction, unstable angina pectoris, ischemic stroke, and transient ischemic attack. Survivors of each cardiovascular event are at risk of a more severe recurrent event.


Real-World Data provides evidence of what is happening for the patients in real-life clinical setting, which actually may differ from the results obtained from clinical trials. In this study, the risk of death after the second cardiovascular event was higher than reported in previous clinical trials, indicating the importance of studies utilizing RWD. RWE studies include the entire patient population without any selection criterion, which may differ from clinical trial setting.

Liisa Ukkola-Vuoti

Read the Original

This page is a summary of: Cardiovascular event rate and death in high‐risk secondary prevention patient cohort in Finland: A registry study, Clinical Cardiology, March 2022, Wiley,
DOI: 10.1002/clc.23814.
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