Nanoscale Fluorescent Metal-Organic Framework@Microporous Organic Polymer Composites for Enhanced Intracellular Uptake and Bioimaging

Lei Wang, Weiqi Wang, Xiaohua Zheng, Zhensheng Li, Zhigang Xie
  • Chemistry - A European Journal, December 2016, Wiley
  • DOI: 10.1002/chem.201604416

Organic Polymer Composites for Enhanced Intracellular Uptake and Bioimaging

What is it about?

Polymer-modified metal–organic frameworks combine the advantages of both soft polymers and crystalline metal–organic frameworks (MOFs). It is a big challenge to develop simple methods for surface modification of MOFs. In this work, MOF@microporous organic polymer (MOP) hybrid nanoparticles (UNP) have been synthesized by epitaxial growth of luminescent boron-dipyrromethene (BODIPYs)–imine MOPs on the surface of UiO-MOF seeds, which exhibit low cytotoxicity, smaller size distribution, wellretained pore integrity, and available functional sites. After folic acid grafting, the enhanced intracellular uptake and bioimaging was validated.

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http://dx.doi.org/10.1002/chem.201604416

The following have contributed to this page: Xiaohua Zheng