What is it about?
Two ambient-stable palladium catalysts that efficiently catalyze the C-C bond formation were demonstrated. After the NHC-PdCl2-P(tolyl)2(OH) (the lock) catalyst is deprotonated by base (the key), the remarkable capability of catalysis is released and tuned by the size of alkali cations. A new lock-and-key strategy is firstly reported for further development of palladium catalysts.
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Why is it important?
Two highly effective palladium catalysts were designed and successfully synthesized. We proposed an activating mechanism for the ambient-stable precatalysts, NHC-PdCl2-PR2(OH), with experimental and theoretical evidence. Our significant finding is that the remarkably effective active species is anionic Pd(0)-PR2(O-) via the unexpected dissociation of a strong NHC ligand. This work may spur the use of deprotonatable phosphinous acid as auxiliary ligand in catalysis.
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This page is a summary of: Reactivity‐Tunable Palladium Precatalysts with Favorable Catalytic Properties in Suzuki–Miyaura Cross‐Coupling Reactions, ChemCatChem, July 2022, Wiley, DOI: 10.1002/cctc.202200736.
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