What is it about?
Two ambient-stable palladium catalysts that efficiently catalyze the C-C bond formation were demonstrated. After the NHC-PdCl2-P(tolyl)2(OH) (the lock) catalyst is deprotonated by base (the key), the remarkable capability of catalysis is released and tuned by the size of alkali cations. A new lock-and-key strategy is firstly reported for further development of palladium catalysts.
Photo by Chromatograph on Unsplash
Why is it important?
Two highly effective palladium catalysts were designed and successfully synthesized. We proposed an activating mechanism for the ambient-stable precatalysts, NHC-PdCl2-PR2(OH), with experimental and theoretical evidence. Our significant finding is that the remarkably effective active species is anionic Pd(0)-PR2(O-) via the unexpected dissociation of a strong NHC ligand. This work may spur the use of deprotonatable phosphinous acid as auxiliary ligand in catalysis.
Read the Original
This page is a summary of: Reactivity‐Tunable Palladium Precatalysts with Favorable Catalytic Properties in Suzuki–Miyaura Cross‐Coupling Reactions, ChemCatChem, July 2022, Wiley,
You can read the full text:
The following have contributed to this page