What is it about?

This study provided the first evidence that high CD73 expression associated with high TGF- production by cervical cancer cells cultured as tumorspheres strongly contributes to the induction of protumoral characteristics related to tumor progression, such as migration and invasiveness, immune evasion, immunosuppression, and chemoresistance.

Featured Image

Why is it important?

The presence of the TGF-b-CD73–Adenosine feedback loop can promote protumoral characteristics in the cervical cancer tumor microenvironment.

Perspectives

The protumoral role of the TGF-b-CD73–Adenosine feedback loop in cervical cancer microenvironment has clinical importance as a therapeutic target

ALBERTO MONROY-GARCIA
Universidad Nacional Autonoma de Mexico

Read the Original

This page is a summary of: Evidence that cervical cancer cells cultured as tumorspheres maintain high CD73 expression and increase their protumor characteristics through TGF‐β production, Cell Biochemistry and Function, September 2022, Wiley, DOI: 10.1002/cbf.3742.
You can read the full text:

Read

Contributors

The following have contributed to this page