What is it about?
Orthodontic treatment requires physiological periodontal tissue remodeling following the application of a corrective force to displaced teeth. The important biological basis of orthodontic tooth movement is the delicate interaction of osteoblasts and osteoclasts to achieve tooth movement within a physiological range. On the other hand, the mammalian target of rapamycin (mTOR), which is involved in the gene transcription, protein translation, ribosome biogenesis and other biological processes, is an atypical serine/threonine protein kinases involved in the regulation of cell growth, proliferation and differentiation through the PI3K/Akt/mTOR/P70S6K signaling pathway.
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Why is it important?
However, no study has investigated the effect of applied force on PI3K, Akt, P70S6K expression in the human periodontal ligament PDL. Previous studies undoubtedly have laid a solid theoretical foundation for PI3K, Akt, P70S6K in relation to the acceleration of orthodontic tooth movement. Therefore, the aim of the present study was to investigate PI3K, Akt, P70S6K expression in the human PDL as a result of a delivered orthodontic force. The second aim was to study PI3K, Akt, and P70S6K expression more objectively in the clinical process and interpret the mTOR signaling pathway during orthodontic tooth movement.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. It is an issue that touches every single human being on this planet in one way or another. More than anything else, and if nothing else, I hope you find this article thought-provoking.
Yuejiao Zhang
China Medical University
Read the Original
This page is a summary of: Effect of orthodontic force on the expression of PI3K, Akt, and P70S6 K in the human periodontal ligament during orthodontic loading, Cell Biochemistry and Function, August 2017, Wiley,
DOI: 10.1002/cbf.3284.
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