What is it about?
Although anti-oestrogens tamoxifen and letrozole have been used for more than a decade, less is known about the side effects of these treatments on thyroid function. Breast cancer patients gain on average 1-5 kg during the treatment with chemotherapy/anti-oestrogens, yet for unknown reasons. We performed a systematic review to examine if tamoxifen/letrozole can influence thyroid function and thereby can partly explain weight gain in patients treated for breast cancer.
Photo by National Cancer Institute on Unsplash
Why is it important?
Side-effects of cancer treatments can influence the quality of life. Despite great advances in cancer treatments during the last decade, less is known about treatment-related side effects and reasons for weight gain. Our findings show that tamoxifen can influence thyroid function, being the risk of subclinical hypothyroidism and probaly weight gain.
Read the Original
This page is a summary of: Influence of the anti‐oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review, Cancer Medicine, June 2022, Wiley, DOI: 10.1002/cam4.4949.
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