What is it about?

PCSK9 has a crucial role in lipid metabolism, particularly due to its function in low-density lipoprotein receptor degradation. In recent years, PCSK9 has become an important therapeutic target for cholesterol-lowering therapy. Particularly, its inhibition with monoclonal antibodies has shown excellent efficacy in decreasing LDL-C and reducing cardiovascular events. However, PCSK9, first identified in the brain, seems to be a ubiquitous protein with different tissue-specific functions also independent of cholesterol metabolism.

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Why is it important?

PCSK9 appears to be involved in the immune response, hemostasis, glucose metabolism, neuronal survival, and several other biological functions. What may be the long-term results of its inhibition?

Perspectives

This review provides a comprehensive overview of the genetics, biochemical structure, expression, and function of PCSK9 and discusses the potential implications of its long-term pharmacological inhibition.

Arturo Cesaro
Seconda Universita degli Studi di Napoli

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This page is a summary of: Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for long‐term inhibition, BioFactors, January 2020, Wiley, DOI: 10.1002/biof.1619.
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