What is it about?
PCSK9 has a crucial role in lipid metabolism, particularly due to its function in low-density lipoprotein receptor degradation. In recent years, PCSK9 has become an important therapeutic target for cholesterol-lowering therapy. Particularly, its inhibition with monoclonal antibodies has shown excellent efficacy in decreasing LDL-C and reducing cardiovascular events. However, PCSK9, first identified in the brain, seems to be a ubiquitous protein with different tissue-specific functions also independent of cholesterol metabolism.
Featured Image
Photo by Bill Oxford on Unsplash
Why is it important?
PCSK9 appears to be involved in the immune response, hemostasis, glucose metabolism, neuronal survival, and several other biological functions. What may be the long-term results of its inhibition?
Perspectives
This review provides a comprehensive overview of the genetics, biochemical structure, expression, and function of PCSK9 and discusses the potential implications of its long-term pharmacological inhibition.
Arturo Cesaro
Seconda Universita degli Studi di Napoli
Read the Original
This page is a summary of: Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for long‐term inhibition, BioFactors, January 2020, Wiley,
DOI: 10.1002/biof.1619.
You can read the full text:
Resources
Contributors
The following have contributed to this page
