Catheter-associated bladder trauma: An experimental study in pigs

What is it about?

This study aimed to characterize bladder mucosal trauma associated with intermittent catheterization using conventional eyelet catheters (CECs) and to assess if a microhole zone catheter (MHZC) design concept reduces this adverse effect. A porcine model was developed to reflect human catheterization and bladder drainage. Nine pigs were randomized for catheterization with CEC (n = 6) or MHZC (n = 3). The bladder was drained repeatedly 20 times through the catheter. Cystoscopy was performed before and after the procedure, and bladders were analyzed by histopathology. Results showed that CECs induced macroscopic and histopathological lesions, while MHZCs did not. The study suggests that rethinking basic catheter designs can reduce the risk of urinary tract infections associated with traditional ICs. The pig model was found to be an attractive option for investigating catheter performances. [Some of the content on this page has been created by AI]

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Why is it important?

This research is important as it highlights the potential risks associated with conventional eyelet catheters (CECs) used for intermittent catheterization (IC) and proposes a redesign of catheters to minimize these risks. The study found that CECs cause significant mucosal bladder trauma, which may contribute to urinary tract infections (UTIs) and discomfort for users. The findings suggest that a redesign of catheters could potentially reduce these risks and improve the quality of life for users. Key Takeaways: 1. Conventional eyelet catheters (CECs) used for intermittent catheterization (IC) cause significant mucosal bladder trauma, which may contribute to urinary tract infections (UTIs) and discomfort for users. 2. A novel catheter design based on microhole zone technology reduces the pressure associated with suction events and inflicts significantly less tissue trauma. 3. Pigs are an attractive animal model for investigating catheter performances, as they are large enough to accurately recapitulate human bladder anatomy and support catheter sizes designed for adults.